In a seminal published in 1950 in the British Medical Journal, Hans Selye MD, PhD, described the human physiological response to prolonged stress as a General Adaptation Syndrome (GAS). Selye identified the three stages of General Adaptation Syndrome - alarm, resistance, and exhaustion - as a guide to assist healthcare professionals with their evaluation and early intervention strategies.

While he illustrated the clinical utility of identifying these stages associated with GAS, he also cautioned, "The general adaptation syndrome never occurs in its pure form, but is always complicated by superimposed specific actions of the eliciting stressors." The impact of stress is a spectrum requiring thorough practitioner analysis of each patient. And the impact of stress on what is now referred to as the hypothalamic-pituitary-adrenal (HPA) axis is individualized and varied in its outcome.

This HPA Axis Optimization Program is designed to help you accurately assess common and complex symptoms within various stress response stages - thereby improving patients' ability to respond and adapt to stressful stimuli while promoting energy recovery and restorative sleep.

Program Tools

Brochure: HPA Axis Optimization Program

An introduction to the HPA Axis Optimization Program, including an overview of the HPA axis, and stress response.

Assessment & Nutritional Therapies Guide

This physician-reviewed guide contains information designed to assist in your assessment of patients in various stages of physiological stress and to guide in the selection of appropriate nutritional supplements.


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*This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.